Totally cool subject, that I was/am able to keep continued education on. Like so many things we talk about, this is a complicated subject. Pharmacology is kinetics(what we are talking about) and dynamics basically. Kinetics what body and homeostatis does to drugs and dynamics is what drugs and interactions do to body. All sorts of formulas in kinetics is how the drug moves through absorption, excretion… Etc. Dynamics is half live, activity… So trying to keep it real simple anavar was at 2.5mgs because in a normal situation(key word) that drug passed unchanged and had better affinity then maybe ANADROL which was 50mgs. This is important with vanco or chemotherapy cancer agents where lethal dose is close to effective dose. I guess it could be a certain percentage absorption of proviron could be 4mg of 25, the rest excreted, binded. Everything is taken into effect… Age, enzyme concen. , weight, with food/without ad naseum. So what’s scary and why we need open and honest communication is what if I say compound A worked great at 500mgs a week. You have a addiction to grapefruit juice😊 grape fruit juice enhances absorption of compound A by 200%. You take 500mgs and get I’ll after every shot for three days… I’m an idiot don’t listen to him! 100mgs was ok but… And so we get bro science. But as numbers go up we tend to come out with the right amt over time.